SML0238
WEB2086
≥98% (HPLC)
동의어(들):
3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone, Apafant, WEB 2086BS
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모든 사진(1)
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5 MG
₩257,506
25 MG
₩1,026,977
About This Item
실험식(Hill 표기법):
C22H22ClN5O2S
CAS Number:
Molecular Weight:
455.96
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
DMSO: 10 mg/mL (clear solution)
저장 온도
2-8°C
SMILES string
Cc1nnc2CN=C(c3ccccc3Cl)c4cc(CCC(=O)N5CCOCC5)sc4-n12
InChI
1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
InChI key
JGPJQFOROWSRRS-UHFFFAOYSA-N
생화학적/생리학적 작용
WEB 2086 inhibits PAF mediated chemotaxis and leukotriene C4 production in eosinophils.[1] It prevents surge in airway resistance and cardiovascular side effects mediated by PAF inhalation.[2]
WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist (IC50 = 16 nM). WEB2086 inhibits the proliferation of tumor cells and slows tumor growth in xenograft tumor models, and has been shown to inhibit angiogenesis.
WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist.
특징 및 장점
This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Eduardo Tibiriçá et al.
Journal of ethnopharmacology, 111(1), 50-55 (2006-12-08)
We investigated the vascular effects of a crude aqueous extract (AEEG) of Echinodorus grandiflorus (Alismataceae) using the in vitro experimental models of the rabbit isolated aorta and perfused kidney. Echinodorus grandiflorus, a native semi-aquatic plant widely distributed in Brazil, has
Evandro M M Machado et al.
Journal of insect physiology, 52(7), 685-692 (2006-06-17)
The effects of the triazolodiazepine WEB 2086, a platelet-activating factor (PAF) antagonist, on hemocyte microaggregation and prophenoloxidase (proPO)-activating system in the hemolymph, hemocoelic infection and mortality in fifth-instar larvae of Rhodnius prolixus inoculated with Trypanosoma rangeli were investigated. Hemocoelic injection
Inhibitory effects of the new PAF acether antagonist WEB-2086 on pharmacologic changes induced by PAF inhalation in human beings
Adamus WS, et al.
Clinical Pharmacology, 47(4), 456-462 (1990)
Marcela B Figueiredo et al.
Journal of insect physiology, 54(2), 344-350 (2007-11-27)
The hemocytes phagocytosis in response to microorganisms may play an important role in the cellular immune responses of insects. Here, we have evaluated the effects of the platelet-activating factor (PAF) and eicosanoids in the phagocytosis of hemocyte monolayers of Rhodnius
Yoichi Ajiro et al.
American journal of physiology. Heart and circulatory physiology, 301(6), H2395-H2401 (2011-09-29)
Sodium-hydrogen exchanger (NHE), the principal sarcolemmal acid extruder in ventricular myocytes, is stimulated by a variety of autocrine/paracrine factors and contributes to myocardial injury and arrhythmias during ischemia-reperfusion. Platelet-activating factor (PAF; 1-o-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent proinflammatory phospholipid that is released
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