A8727
Antalarmin hydrochloride
≥98% (HPLC), solid, CRF1 antagonist
동의어(들):
N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride
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모든 사진(1)
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10 MG
₩420,312
50 MG
₩1,524,226
About This Item
실험식(Hill 표기법):
C24H34N4·HCl
CAS Number:
Molecular Weight:
415.01
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
Antalarmin hydrochloride, ≥98% (HPLC), solid
Quality Level
분석
≥98% (HPLC)
양식
solid
저장 조건
desiccated
색상
off-white
solubility
DMSO: >10 mg/mL
저장 온도
2-8°C
SMILES string
Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
InChI
1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChI key
CGDGXEDXEXACKQ-UHFFFAOYSA-N
애플리케이션
Antalarmin hydrochloride has been used:
- to study its effect on stress-induced tryptophan hydroxylase 2 activity[1]
- to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation[2][3]
- to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression[4]
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.
생화학적/생리학적 작용
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.
Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.[5]
특징 및 장점
This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
Cecile Ducottet et al.
Progress in neuro-psychopharmacology & biological psychiatry, 27(4), 625-631 (2003-06-06)
Several recent studies on corticotropin-releasing factor (CRF) have suggested that this neuropeptide may play a role in depression. Consequently, CRF receptor antagonists have been proposed as potential new agents for the treatment of this condition. This study investigated the effects
Pediatric Neuroendocrinology, 41-41 (2010)
Deficits in KCC2 and activation of the HPA axis lead to depression-like behavior following social defeat
Miller S and Maguire J
Hormonal Studies, 2(1), 2-2 (2014)
CRF type 1 receptors of the medial amygdala modulate inhibitory avoidance responses in the elevated T-maze
Vicentini JE, et al.
Hormones and Behavior, 65(3), 195-202 (2014)
Anna Skórzewska et al.
Stress (Amsterdam, Netherlands), 22(1), 113-122 (2018-10-23)
This study aimed to test the hypothesis that high-anxiety (HR) rats are more sensitive to the effects of chronic corticosterone administration and antalarmin (corticotropin-releasing factor (CRF) receptor 1, CRF1 antagonist) injections than low-anxiety (LR) rats, and this effect is accompanied
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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