Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
추천 제품
Quality Level
양식
solution
농도
10 mg/mL in DMSO
항생제 활성 스펙트럼
fungi
동작 모드
cell membrane | interferes
저장 온도
−20°C
SMILES string
C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI key
GBOGMAARMMDZGR-TYHYBEHESA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Cytochalasin B from Drechslera dematioidea has been used:
- to block cytokinesis, to obtain binucleated cells[1]
- as a specific glucose transporter inhibitor[2]
- to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells[3]
생화학적/생리학적 작용
Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.[7]
One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.
기타 정보
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 2
Flash Point (°F)
185.0 °F - closed cup - Solvent
Flash Point (°C)
85 °C - closed cup - Solvent
개인 보호 장비
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Alternative In Vitro Models for Safety and Toxicity Evaluation of Nutraceuticals
Nutraceuticals, 355-385 (2016)
Adam R Akkad et al.
PloS one, 17(5), e0268508-e0268508 (2022-05-21)
Biological materials can be shipped off-site for diagnostic, therapeutic and research purposes. They usually are kept in certain environments for their final application during transportation. However, active reagent handling during transportation from a collection site to a laboratory or biorepository
Michael V Zuccaro et al.
Cell, 183(6), 1650-1664 (2020-10-31)
Correction of disease-causing mutations in human embryos holds the potential to reduce the burden of inherited genetic disorders and improve fertility treatments for couples with disease-causing mutations in lieu of embryo selection. Here, we evaluate repair outcomes of a Cas9-induced
[18 F] FDG PET signal is driven by astroglial glutamate transport
Zimmer ER, et al.
Nature Neuroscience, 20(3), 393-393 (2017)
Human Cytomegalovirus Activates Glucose Transporter 4 Expression To Increase Glucose Uptake during Infection
Yu Y, et al.
Journal of virology, 85(4), 1573-1580 (2011)
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What is the Department of Transportation shipping information for this product?
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도움이 되었습니까?
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Is Product C2743, Cytochalasin B, cell culture grade?
1 답변-
The product has been sterile filtered, but it has not been cell culture tested by Sigma.
도움이 되었습니까?
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
도움이 되었습니까?
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I have a solution of Product C2743, Cytochalasin B, in DMSO. Is the DMSO toxic to cultured cells?
1 답변-
At a low enough concentration, the DMSO should not hurt the cells. The final concentration of DMSO in the aqueous working medium typically should not exceed 0.1% because higher DMSO concentrations can adversely affect many cultured cells. Dilute the product in the appropriate aqueous medium to provide a physiologically acceptable final concentration.
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