콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

C1617

Sigma-Aldrich

C Reactive Protein human

recombinant, expressed in E. coli, liquid

동의어(들):

CRP

로그인조직 및 계약 가격 보기


About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.32
가격 및 재고 정보를 현재 이용할 수 없음 고객지원팀으로 연락바랍니다.

재조합

expressed in E. coli

Quality Level

양식

liquid

분자량

23 kDa

bp

~100 °C

UniProt 수납 번호

저장 온도

2-8°C

유전자 정보

human ... CRP(1401)

일반 설명

C-reactive protein (CRP), a homopentameric acute-phase inflammatory protein, is produced mainly in liver hepatocytes. This highly conserved plasma protein is also produced by smooth muscle cells, macrophages, endothelial cells, lymphocytes, and adipocytes. It belongs to the pentraxin family.[1]

애플리케이션

C Reactive Protein human has been used:
  • as a component in differentiation medium to study the effects of C-reactive protein (CRP) on the size of myotubes and myotube mixed protein synthesis (MPS)[2]
  • to study the influence of serum CRP level from elderly on endothelial cell proliferation in human umbilical vein endothelial cells (HUVEC)[3]
  • to study the roles and connections of nicotine, monocytic interleukin 6 (IL-6), α7 nicotinic acetylcholine receptor (α7-nAChR), and CRP in the development of coronary artery spasm (CAS)[4]

생화학적/생리학적 작용

C-reactive protein (CRP) is a protein that could precipitate the C-polysaccharide of pneumococcal cell walls. CRP is widely used as a clinical marker of the state of inflammation, since its production by hepatocytes increases during the acute phase of the inflammatory response.
C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.[1]

분석 메모

A highly purified protein and made by a fermentation process using genetically modified E. coli.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

이미 열람한 고객

Adrian Hosford-Donovan et al.
Maturitas, 89, 52-57 (2016-05-18)
It is hypothesized that chronic systemic inflammation contributes to the age-related decline in cardiovascular function. The aim of the present study was to combine an assessment of the relationship between the serum level of C-reactive protein (CRP) and systolic and
Ming-Yow Hung et al.
Free radical biology & medicine, 120, 266-276 (2018-04-03)
Smoking and high-sensitivity C-reactive protein (hs-CRP) are risk factors for coronary artery spasm (CAS), which is characterized by the increased interleukin-6 (IL-6) level and monocyte counts; however, limited data are available regarding the role of cigarette-embedded nicotine in the modulation
P P Galanis et al.
Talanta, 238(Pt 2), 123056-123056 (2021-11-22)
We report the use of a laser-based fabrication process in the creation of paper-based flow-through filters that when combined with a traditional lateral flow immunoassay provide an alternative pathway for the detection of a pre-determined analyte over a wide concentration
Britta Wåhlin-Larsson et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 44(1), 267-278 (2017-11-14)
Mechanisms underlying the relationship between systemic inflammation and age-related decline in muscle mass are poorly defined. The purpose of this work was to investigate the relationship between the systemic inflammatory marker CRP and muscle mass in elderly and to identify
Nicola R Sproston et al.
Frontiers in immunology, 9, 754-754 (2018-05-01)
C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of inflammation and infection

질문

1–2 / 2 질문  
  1. What is the Department of Transportation shipping information for this product?

    1 답변
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      도움이 되었습니까?

  2. How is the protein concentration of product C1617, human recombinant C-Reactive Protein, determined?

    1 답변
    1. The absorbance of the solution at 280 nm is read and the protein concentration calculated using an E(1%) of 17.

      도움이 되었습니까?

후기

평점 값 없음

활성 필터

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.