A9657

DL-Aminoglutethimide

• 동의어(들): 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione, 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione
• 실험식(Hill 표기법): C₁₃H₁₆N₂O₂
• CAS Number: 125-84-8
• Molecular Weight: 232.28
• EC Number: 204-756-4
• MDL number: MFCD00010122
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278142
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• 분석: ≥98% (TLC)
• 양식: powder or crystals
• 색상: white
• mp: 152-154 °C (lit.)
• solubility: H₂O: slightly soluble 0.2 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.2 mg/mL; 0.1 M HCl: soluble; acetonitrile: soluble; methanol: soluble
• 주관자: Novartis
• 저장 온도: room temp
• SMILES string: CCC1(CCC(=O)NC1=O)c2ccc(N)cc2
• InChI: 1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
• InChI key: ROBVIMPUHSLWNV-UHFFFAOYSA-N
• 유전자 정보: human ... CYP11A1(1583) , CYP17A1(1586) , CYP19A1(1588) ; rat ... Cyp19a1(25147)

설명

애플리케이션

DL-Aminoglutethimide has been used:

• as a steroid synthesis inhibitor to study its effects on steroid synthesis in amphibian Xenopus laevis oocytes[1]
• as an adrenostatic compound to study its effects on full form Enhanced green fluorescent protein (EGFP) andproopiomelanocortin (POMC) expression in the anterior domain of zebrafish pituitary corticotrophs[2]
• as an inhibitor of steroidogenic enzymes to study its effects on estrogen receptor (ER) mRNA levels in mouse tumor leydig cell line [3]

생화학적/생리학적 작용

DL-Aminoglutethimide is a derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. It also blocks the peripheral conversion (aromatization) of androgenic precursors to estrogens. The D-isomer is 30 times more potent at inhibiting aromatase activity, whereas the L-isomer is more potent at inhibiting cholesterol side-chain cleavage (steroidogenesis).

Derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone.

특징 및 장점

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves