A8986
Alexidine dihydrochloride
≥95% (HPLC)
동의어(들):
1,1′-Hexamethylene-bis(5-[2-ethylhexyl]biguanide)
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크기 선택
10 MG
₩131,747
50 MG
₩526,379
모든 사진(1)
크기 선택
보기 변경
10 MG
₩131,747
50 MG
₩526,379
About This Item
실험식(Hill 표기법):
C26H56N10 · 2HCl
CAS Number:
Molecular Weight:
581.71
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥95% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to off-white
solubility
DMSO: ≥10 mg/mL
저장 온도
−20°C
SMILES string
Cl.Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC
InChI
1S/C26H56N10.2ClH/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2;;/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);2*1H
InChI key
BRJJFBHTDVWTCJ-UHFFFAOYSA-N
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애플리케이션
Alexidine dihydrochloride has been used:
- as an antiseptic to study its antimicrobial activity in saliva-derived microcosm biofilms[1]
- as a protein tyrosine phosphatase localized to the mitochondrion 1 (PTPMT1)-specific inhibitor to study its effects on spare respiratory capacity and viability of CD8+ T cells[2]
- as a PTPMT1 inhibitor to study its antiviral effect on human cytomegalovirus (HCMV) replication in HCMV-infected human foreskin fibroblast (HFF) cells[3]
생화학적/생리학적 작용
Alexidine dihydrochloride is a bisbiguanide compound. It has been studied in the treatment of head and neck cancer.[4] Alexidine dihydrochloride also exhibits antibiofilm and antifungal activity against several fungal species. It causes mitochondrial apoptosis in mammalian cells due to its anti-cancer activity.[5] Alexidine dihydrochloride is a component of oral disinfectant and contact lens solution.[6]
Alexidine dihydrochloride is a potent and selective PTPMT1 (Protein Tyrosine Phosphatase Localized to the Mitochondrion 1) inhibitor. Alexidine increases insulin secretion by isolated rat pancreatic islets.
특징 및 장점
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Zeinab Mamouei et al.
mSphere, 3(5) (2018-11-02)
Invasive fungal infections due to Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans constitute a substantial threat to hospitalized immunocompromised patients. Further, the presence of drug-recalcitrant biofilms on medical devices and emergence of drug-resistant fungi, such as Candida auris, introduce treatment
Allison Campolo et al.
Pathogens (Basel, Switzerland), 10(2) (2021-01-31)
Acanthamoeba keratitis (AK) is a serious ocular infection caused by a ubiquitous free-living amoeba, Acanthamoeba. This infection often results in extensive corneal damage and blindness, and is notoriously difficult to cure. While Acanthamoeba is an abundant organism, AK is most
Mateja Zorko et al.
The Journal of antimicrobial chemotherapy, 62(4), 730-737 (2008-07-19)
Many antibiotics used to treat infections cause release of immunostimulatory cell wall components from bacteria. Therefore, a combination of antimicrobial and endotoxin-neutralizing activity is desired to prevent inflammation induced by destroyed bacteria. Chlorhexidine and alexidine are amphipathic bisbiguanides and could
M Addy et al.
Journal of clinical periodontology, 8(3), 220-230 (1981-06-01)
A blind cross-over trial was carried out to compare the tooth and tongue staining associated with the use of a 0.035% alexidine and a 0.2% chlorhexidine mouthrinse. Twenty-two volunteers were divided into two groups termed "tea drinkers" and "non-tea drinkers".
J Moran et al.
Journal of periodontology, 55(5), 278-282 (1984-05-01)
The phenomenon of surface adsorption appears fundamental to the antiplaque activity of the cationic antiseptics. Moreover, reaction with chromogenic material is relevant to the local side effect of staining. The purpose of this investigation was to determine how such local
문서
Protein tyrosine phosphatases' catalytic mechanism involves transient phosphorylation.
활성 필터
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