G1404

Glutathione reduced ethyl ester

≥90% (TLC)

• 동의어(들): γ-Glu-Cys-Gly-OEt, GSH-MEE
• 실험식(Hill 표기법): C₁₂H₂₁N₃O₆S
• CAS Number: 92614-59-0
• Molecular Weight: 335.38
• MDL number: MFCD00156117
• UNSPSC 코드: 12161504
• PubChem Substance ID: 329799840
• NACRES: NA.26

속성

• product name: Glutathione reduced ethyl ester, ≥90% (TLC)
• 분석: ≥90% (TLC)
• 형태: powder
• 색상: white to off-white
• 저장 온도: −20°C
• SMILES string: CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
• InChI key: JKRODHBGNBKZLE-YUMQZZPRSA-N

설명

Amino Acid Sequence

Glu-Cys-Gly-OEt

애플리케이션

Glutathione reduced ethyl ester has been used:

• to increase intracellular glutathione levels in mouse fibroblast L929 cells
• as a medium supplement in Spodoptera frugiperda (Sf)9 cells
• to evaluate its effect on lipid peroxidation after spinal cord injury

생화학적/생리학적 작용

Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.

Glutathione reduced ethyl ester inhibits melanin synthesis by inhibiting tyrosinase activity in Melan-A cells. Its antimelanogenic functionality has potential in treating hyperpigmentation skin disorders. GEE supplementation during islets isolation form pancreas reduces reactive oxygen species production and apoptosis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)