917354

tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate

• 동의어(들): Semi-flexible linker for PROTAC^® development
• 실험식(Hill 표기법): C₁₇H₂₆N₂O₂
• CAS Number: 1198286-87-1
• Molecular Weight: 290.40
• MDL number: MFCD09038246
• UNSPSC 코드: 12352200

속성

• 형태: powder
• Quality Level: 100
• 반응 적합성: reagent type: linker
• 작용기: Boc; amine
• 저장 온도: 2-8°C
• SMILES string: O=C(N(CC1)CCC1C(C=C2)=CC=C2CN)OC(C)(C)C

설명

애플리케이션

tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

기타 정보

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable