917400

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate

≥95%

• 동의어(들): Semi-flexible linker for PROTAC^® development
• 실험식(Hill 표기법): C₁₇H₂₅NO₃
• CAS Number: 909422-39-5
• Molecular Weight: 291.39
• MDL number: MFCD30099260
• UNSPSC 코드: 12352116
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: ≥95%
• 형태: powder
• 반응 적합성: reagent type: linker
• 작용기: Boc; hydroxyl
• 저장 온도: 2-8°C
• SMILES string: O=C(N(CC1)CCC1C2=CC(CO)=CC=C2)OC(C)(C)C

설명

애플리케이션

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

기타 정보

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H315,H317,H319,H410
• 예방조치 성명서: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable