61188

Losartan potassium

• 동의어(들): 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt, DuP 753, MK 954, Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
• 실험식(Hill 표기법): C₂₂H₂₂ClKN₆O
• CAS Number: 124750-99-8
• Molecular Weight: 461.00
• Beilstein: 5845770
• MDL number: MFCD02092704
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329759382
• NACRES: NA.24

속성

• 형태: powder or crystals
• Quality Level: 200
• 유통기한: limited shelf life, expiry date on the label
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 불순물: ≤0.5% water
• 응용 분야: forensics and toxicology; pharmaceutical (small molecule); veterinary
• SMILES string: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• InChI key: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• 유전자 정보: human ... AGTR1(185)

설명

일반 설명

Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.

Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.

애플리케이션

Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:

• Pharmaceutical formulations using reversed-phase high-performance liquid chromatography and UV-spectrophotometric techniques.
• Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

생화학적/생리학적 작용

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

추천 제품

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)