T8949

Telmisartan

≥98% (HPLC), solid

• 동의어(들): 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid, BIBR 277
• 실험식(Hill 표기법): C₃₃H₃₀N₄O₂
• CAS Number: 144701-48-4
• Molecular Weight: 514.62
• MDL number: MFCD00918125
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826889
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: solid
• 색상: white
• solubility: DMSO: >5 mg/mL at 60 °C; H₂O: insoluble
• 주관자: Boehringer Ingelheim
• SMILES string: CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C
• InChI: 1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
• InChI key: RMMXLENWKUUMAY-UHFFFAOYSA-N
• 유전자 정보: human ... AGTR1(185)

설명

애플리케이션

Telmisartan has been used as an AT1 receptor antagonist to study its effects on mouse models of myocardial infarction. This study reported that telmisartan inhibited the CCN1 upregulation and reduced CCN2 levels atrial cardiomyocytes. Telmisartan has also been used to evaluate its effect on the expression of CCN1 in kidney cortex of mice subjected to myocardial infarction. Furthermore, telmisartan has been used to test its efficacy against tumor growth in mouse models of colorectal cancer.

생화학적/생리학적 작용

Telmisartan is a non-peptide AT₁ angiotensin receptor antagonist.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

Telmisartan is soluble in DMSO at a concentration that is greater than 5 mg/ml. It is insoluble in water.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)