추천 제품
생물학적 소스
mouse
항체 형태
ascites fluid
항체 생산 유형
primary antibodies
클론
monoclonal
종 반응성
human
제조업체/상표
Chemicon®
기술
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
동형
IgG1κ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... HTT(3064) , SLC6A4(6532)
특이성
Reacts huntingtin protein, amino acids 115-129. The antibody recognizes wild type and mutant huntingtin.
면역원
Epitope: a.a. 115-129
Recombinant human huntingtin, amino acids 115-129.
애플리케이션
Anti-Huntingtin Antibody, a.a. 115-129 detects level of Huntingtin & has been published & validated for use in ELISA, WB, IC, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blot: 1:500-1:5,000
Immunocytochemistry (1): 1:500-1:5,000
Immunohistochemistry (1,2): 1:500-1:5,000
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by end user.
Immunocytochemistry (1): 1:500-1:5,000
Immunohistochemistry (1,2): 1:500-1:5,000
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by end user.
물리적 형태
Ascites fluid. Liquid. Contains no preservative.
저장 및 안정성
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.
Grison, A; Mantovani, F; Comel, A; Agostoni, E; Gustincich, S; Persichetti, F; Del Sal, G
Proceedings of the National Academy of Sciences of the USA null
Jacqueline Gire O'Rourke et al.
Cell reports, 4(2), 362-375 (2013-07-23)
A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain of HTT, show modification downstream of
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Thompson, LM; Aiken, CT; Kaltenbach, LS; Agrawal, N; Illes, K; Khoshnan et al.
The Journal of cell biology null
Katarina Trajkovic et al.
Bio-protocol, 8(1) (2018-01-13)
Quantitative analysis of proteins secreted from the cells poses a challenge due to their low abundance and the interfering presence of a large amount of bovine serum albumin (BSA) in the cell culture media. We established assays for detection of
Tamara Ratovitski et al.
Cell cycle (Georgetown, Tex.), 14(11), 1716-1729 (2015-05-01)
Abnormal protein interactions of mutant huntingtin (Htt) triggered by polyglutamine expansion are thought to mediate Huntington's disease (HD) pathogenesis. Here, we explored a functional interaction of Htt with protein arginine methyltransferase 5 (PRMT5), an enzyme mediating symmetrical dimethylation of arginine
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