ABC835

Anti-SDHD Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, CybS, CII-4, QPs3, Succinate dehydrogenase complex subunit D, Succinate-ubiquinone oxidoreductase cytochrome b small subunit, Succinate-ubiquinone reductase membrane anchor s
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse
• 기술: immunocytochemistry: suitable; western blot: suitable
• UniProt 수납 번호: O14521
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SDHD(6392)

설명

일반 설명

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS), also known as CII-4 or QPs3 or Succinate dehydrogenase complex subunit D or Succinate-ubiquinone oxidoreductase cytochrome b small subunit or Succinate-ubiquinone reductase membrane anchor subunit, and encoded by the gene name SDHD or SD14, is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumorsuppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.

면역원

Epitope: center region

KLH-conjugated synthetic peptide corresponding to the center region of human Anti-SDHD.

애플리케이션

Detect SDHD using this Anti-SDHD Antibody validated for use in western blotting & ICC.

Immunocytochemistry Analysis: 2.5 μg/mL from a representative lot detected Anti-SDHD in EL4 cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

품질

Evaluated by Western Blotting in EL4 cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected Anti-SDHD in EL4 cell lysate.

표적 설명

~16 kDa observed. Uncharacterized bands may be observed in some lysate(s).

물리적 형태

Affinity

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable