676380
Valproic Acid sodium salt
≥98% (HPLC), solid, HDAC1 inhibitor, Calbiochem®
동의어(들):
Valproic Acid, Sodium Salt, 2-Propylpentanoic Acid, Na
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크기 선택
5 G
₩133,676
₩133,676
예상 입고일2025년 4월 03일세부사항
모든 사진(1)
크기 선택
보기 변경
5 G
₩133,676
About This Item
실험식(Hill 표기법):
C8H15NaO2
CAS Number:
Molecular Weight:
166.19
MDL number:
UNSPSC 코드:
12352106
NACRES:
NA.77
₩133,676
예상 입고일2025년 4월 03일세부사항
추천 제품
제품명
Valproic Acid, Sodium Salt, A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1).
Quality Level
설명
Merck USA index - 14, 9913
분석
≥98% (HPLC)
양식
solid
효능
400 μM IC50
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated (hygroscopic)
색상
white
solubility
water: 50 mg/mL
배송 상태
ambient
저장 온도
2-8°C
SMILES string
[Na+].[O-]C(=O)C(CCC)CCC
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChI key
AEQFSUDEHCCHBT-UHFFFAOYSA-M
일반 설명
A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
HDAC1
HDAC1
Product does not compete with ATP.
Reversible: no
포장
Packaged under inert gas
경고
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
기타 정보
Gottlicher, M., et al. 2001. EMBO J.20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res.21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674.
Chen, G., et al. 1999. J. Neurochem.72, 1327.
Knupfer, M.M., et al. 2001. Anticancer Res.21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674.
Chen, G., et al. 1999. J. Neurochem.72, 1327.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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