573125

STAT3 Inhibitor IX, Cpd188

The STAT3 Inhibitor IX, Cpd188, also referenced under CAS 823828-18-8, controls the biological activity of STAT3.

• 동의어(들): STAT3 Inhibitor IX, Cpd188, 4-((3-(Carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid
• 실험식(Hill 표기법): C₁₉H₁₅NO₇S₂
• CAS Number: 823828-18-8
• Molecular Weight: 433.45
• MDL number: MFCD05804524
• UNSPSC 코드: 12352200
• NACRES: NA.28

속성

• Quality Level: 100
• 분석: ≥90% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: beige
• solubility: DMSO: 100 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [S](=O)(=O)(Nc2c3c(c(c(c2)SCC(=O)O)O)cccc3)c1ccc(cc1)C(=O)O
• InChI: 1S/C19H15NO7S2/c21-17(22)10-28-16-9-15(13-3-1-2-4-14(13)18(16)23)20-29(26,27)12-7-5-11(6-8-12)19(24)25/h1-9,20,23H,10H2,(H,21,22)(H,24,25)
• InChI key: CIERPRDYPKVDJO-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable naphthol compound that inhibits IL-6-stimulated STAT3 Tyr⁷⁰⁵ phosphorylation and nuclear translocation in HepG2 cells (IC₅₀ = 73 and 39 µM, respectively) by targeting STAT3 SH2 domain peptide-binding pocket (IC₅₀ = 20 µM against EGFR-derived pY-peptide binding), while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation even at concentrations as high as 300 µM. Shown to preferentially induce apoptosis in cultures expressing constitutively active STAT3 (EC₅₀ = 0.73, 3.96, and 7.01 µM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively), while being less effective against cells without constitutively active STAT3 (EC₅₀ = 15.5 and 17.19 µM in MDA-MB-453 and MCF7 cultures, respectively).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Xu, X., et al. 2009. PLoS One4, e4783.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable