573128

STAT3 Inhibitor XIII, C188-9

The Stat3 Inhibitor XIII, C188-9 controls the biological activity of Stat3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): STAT3 Inhibitor XIII, C188-9, N-(1ʹ,2-Dihydroxy-1,2ʹ-binaphthalen-4ʹ-yl)-4-methoxybenzenesulfonamide, F1113-0789
• 실험식(Hill 표기법): C₂₇H₂₁NO₅S
• CAS Number: 432001-19-9
• Molecular Weight: 471.52
• MDL number: MFCD03141581
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white to pale beige
• solubility: DMSO: 100 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: OC1=C(C2=C(O)C=CC3=C2C=CC=C3)C=C(NS(C(C=C4)=CC=C4OC)(=O)=O)C5=C1C=CC=C5

설명

일반 설명

A cell-permeable binaphthol-sulfonamide that competes against pY proteins for Stat3 SH2 domain binding. Shown to inhibit G-CSF-induced (100 ng/ml for 15 min following 1 h drug pretreatment) Stat3 tyr705 phosphorylation in 6 human AML cell lines (IC₅₀ from 4.1 to 8.3 µM) and 4 primary pediatric AML cultures (IC₅₀ from 8 to 18 µM). Long-term treatments (24 h for lines and 48 h for primary cultures) result in apoptosis induction (Annexin V-PE staining) in 7 AML lines (EC₅₀ from 8.4 to 43.6 µM) and CD34⁺ populations from 5 primary pediatric AML samples (EC₅₀ from 0.8 to25 µM). Selectivity studies using Kasumi-1 cells reveals concomitant inhibitions of G-CSF-stimulated TIE2, MATK, JAK1, and HGFR phosphorylation (by 90%, 50%, 40%, and 40%, respectively; 10 µM C188-9), but not 15 other phosphoproteins (≤30% inhibition), including pERK1/2 and pAKT.

A cell-permeable binaphthol-sulfonamide that competes against pY proteins for Stat3 SH2 domain binding. Shown to inhibit G-CSF-induced Stat3 tyr705 phosphorylation in human AML cell lines and primary cultures (IC₅₀ from 4.1 to 18 µM). Also shown to inhibit G-CSF-stimulated TIE2, MATK, JAK1, and HGFR phosphorylation (by 90%, 50%, 40%, and 40%, respectively; 10 µM C188-9), but not 15 other phosphoproteins (≤30% inhibition), including pERK1/2 and pAKT, in Kasumi-1 cells.

포장

Packaged under inert gas

경고

Toxicity: Toxic (F)

재구성

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Redell, M.S., et al. 2011. Blood112, 355.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable