콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

모든 문서 보기

572201

Millipore

Streptozotocin

An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

동의어(들):

Streptozotocin, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose

로그인조직 및 계약 가격 보기
모든 사진(1)

About This Item

실험식(Hill 표기법):
C8H15N3O7
CAS Number:
18883-66-4
Molecular Weight:
265.22
MDL number:
MFCD00006607
UNSPSC 코드:
12352103

Quality Level

100

분석

≥95% (HPLC)

양식

crystalline solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze

색상

off-white to pale yellow

solubility

water: soluble

양이온 미량물

heavy metals: ≤5 ppm

배송 상태

ambient

저장 온도

−20°C

SMILES string

N(N=O)(C)C(=O)N[C@H]1[C@H](O[C@@H]([C@H]([C@@H]1O)O)CO)O

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

관련 카테고리

일반 설명

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells. A diabetogenic agent.
An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

경고

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

재구성

Unstable in solution; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-20°C).

기타 정보

Kroncke, K.D., et al. 1995. Biol. Chem. Hoppe Seyler376, 179.
Kwon, N.S., et al. 1994. FASEB J.8, 529.
Rasschaert, J., et al. 1992. Endocrinology130, 3522.
Bennett, R.A. and Pegg, A.E. 1981. Cancer Res.41, 2786.
Yamamoto, H., et al. 1981. Nature294, 284.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

FlameHealth hazard
GHS02,GHS08

신호어

Danger

유해 및 위험 성명서

H228,H341,H351

Hazard Classifications

Carc. 2 - Flam. Sol. 1 - Muta. 2

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 4

1 of 4

Nicotinamide ≥98% (HPLC), powder

Sigma-Aldrich

N3376

Nicotinamide

Sodium citrate United States Pharmacopeia (USP) Reference Standard

USP

1613859

Sodium citrate

Tamoxifen ≥99%

Sigma-Aldrich

T5648

Tamoxifen

4-Nitrophenyl α-D-glucopyranoside ≥99%

Sigma-Aldrich

N1377

4-Nitrophenyl α-D-glucopyranoside

Qin Jiang et al.
The Journal of clinical investigation, 130(7), 3833-3847 (2020-04-29)
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism governing pericyte degeneration is poorly understood. Circular RNAs (circRNAs) play important roles in multiple biological
Dezhi Chen et al.
Molecular medicine reports, 23(2) (2020-12-15)
Diabetic cardiomyopathy (DCM) is one of the primary complications of the cardiovascular system due to diabetes‑induced metabolic injury. The present study investigated the autophagy‑associated regulatory mechanisms of long non‑coding RNAs in cardiac pathological changes in diabetes mellitus (DM). Streptozotocin (STZ)‑induced
Zhongkun Ren et al.
Molecular medicine reports, 21(6), 2475-2483 (2020-04-03)
Epigallocatechin-3-gallate (EGCG) is beneficial for inhibiting dyslipidemia and reducing hyperlipidemic risk. The purpose of the present study was to investigate the glycolipid regulatory effects and potential mechanisms of EGCG in a high‑fat diet and streptozotocin‑induced type 2 diabetes mellitus (T2DM) mouse model.

질문

1–2 / 2 질문  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      도움이 되었습니까?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 답변

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      도움이 되었습니까?

후기

평점 값 없음

활성 필터

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.