565610

SC-560

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC₅₀ = 9 nM).

• 동의어(들): SC-560, 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole
• 실험식(Hill 표기법): C₁₈H₁₂F₃IN₂O
• CAS Number: 188817-13-2
• Molecular Weight: 456.20
• MDL number: MFCD02179214
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 200 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
• InChI key: PQUGCKBLVKJMNT-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable, highly potent and selective inhibitor of cyclooxygenase-1 (COX-1; IC₅₀ = 9 nM). Inhibits cyclooxygenase-2 (COX-2) only at higher concentrations (IC₅₀ = 6.3 µM).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
COX-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 9 nM against COX-1

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable