Staurosporine is soluble in ethyl acetate, DMSO at 5 mg/mL, and DMF. It is slightly soluble in chloroform and methanol at 2 mg/mL, and insoluble in water. Stock solutions should be aliquoted, purged with an inert gas, and stored at -20 °C, where they should remain stable for approximately 6 months.
19-123-M
Staurosporine
Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.
동의어(들):
PKC inhibitor, protein kinase C inhibitor
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크기 선택
200 μG
₩484,967
₩484,967
예상 입고일2025년 5월 19일세부사항
모든 사진(1)
크기 선택
보기 변경
200 μG
₩484,967
About This Item
UNSPSC 코드:
12352200
eCl@ss:
32160405
NACRES:
NA.41
₩484,967
예상 입고일2025년 5월 19일세부사항
추천 제품
일반 설명
Suitable for use as a potent inhibitor of PKC and other protein kinases in vitro and in cultured cells.
애플리케이션
Staurosporine has been used as a protein kinase inhibitor to study the ubiquitin-protein ligase E3 component N-recognin 5 (UBR5)-mediated CDC73 regulation at the protein level. Staurosporine has been used to induce apoptosis in CHO-K1 cell lines, followed by cell imaging and extraction of cell lysate for further analysis.[1]
생화학적/생리학적 작용
Staurosporine, a broad-spectrum protein kinase inhibitor, belongs to the indolocarbazole family. It is referred to as a prototypical ATP-competitive kinase inhibitor. Staurosporine is effective against various kinds of cancers. It is commonly used for inducing apoptosis in different types of cells.
품질
Routinely evaluated by Protein Kinase Inhibition Assay
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Aquatic Chronic 4 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Joachim Rudolph et al.
The Enzymes, 34 Pt. B, 157-180 (2013-01-01)
The p21-activated kinases (PAKs) are Ser/Thr kinases in the STE20 kinase family with important roles in regulating cytoskeletal organization, cell migration, and signaling. The PAK enzyme family comprises six members subdivided into two groups: Group I, represented by PAK1, 2
Boyang Chen et al.
Bioelectrochemistry (Amsterdam, Netherlands), 153, 108456-108456 (2023-05-30)
Lower yields and poorer quality of biopharmaceutical products result from cell death in bioreactors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of events that eventually lead
Carl D Bortner et al.
Methods in enzymology, 428, 161-181 (2007-09-19)
The loss of cell volume or cell shrinkage, termed apoptotic volume decrease (AVD), is a classical characteristic of apoptosis. Microscopy, Coulter electronic sizing, and/or flow cytometry has traditionally been the means to measure this characteristic of apoptosis. Although electronic cell
Yasuko Nakajima et al.
Methods in enzymology, 484, 613-630 (2010-11-03)
Electrophysiological experiments in our laboratory have led to the discovery that the cholinergic neurons in the nucleus basalis in the rat forebrain possess constitutively active inward rectifier K(+) channels. Unlike cloned inward rectifier K(+) channels, these constitutively active inward rectifier
Staurosporine: a prototype of a novel class of inhibitors of tumor cell invasion?
C A O'Brian et al.
Journal of the National Cancer Institute, 82(22), 1734-1735 (1990-11-21)
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