5.05877

(S)-(-)-Raclopride

• 동의어(들): (S)-(-)-Raclopride, Dopamine Receptor D2 Antagonist, (S)-Raclopride, Raclopride
• 실험식(Hill 표기법): C₁₅H₂₀Cl₂N₂O₃
• CAS Number: 84225-95-6
• Molecular Weight: 347.24
• MDL number: MFCD02179386
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 100 mM; ethanol: 25 mM
• 저장 온도: 2-8°C
• SMILES string: Clc1c(c(c(c(c1)Cl)O)C(=O)NC[C@@H]2N(CCC2)CC)OC
• InChI: 1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1
• InChI key: WAOQONBSWFLFPE-SECBINFHSA-N

설명

일반 설명

D₂-like dopamine receptor antagonist targeting D₂R (pKi =8.0), D₃R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D₂ like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D₂ Receptor selectivity in various preps shows IC₅₀ values around 32 nM.

생화학적/생리학적 작용

Reversible: yes

경고

Toxicity: Standard Handling (A)

기타 정보

Dang, Y. H. et al. 2010. Neurosci.169, 1872.

Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable