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Merck
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R121

Sigma-Aldrich

S(−)-Raclopride (+)-tartrate salt

>97%, solid

동의어(들):

3,5-Dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxybenzamide (+)-tartrate salt

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크기 선택

25 MG
₩306,632
100 MG
₩927,913

₩306,632

구입 가능 여부는 고객센터에 문의하십시오.
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
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모든 사진(1)

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보기 변경
25 MG
₩306,632
100 MG
₩927,913

About This Item

실험식(Hill 표기법):
C15H20Cl2N2O3 · C4H6O6
CAS Number:
98185-20-7
Molecular Weight:
497.32
MDL number:
MFCD00274072
UNSPSC 코드:
12352200
PubChem Substance ID:
24277931
NACRES:
NA.77

₩306,632

구입 가능 여부는 고객센터에 문의하십시오.
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
벌크 견적 요청

분석

>97%

양식

solid

색상

white

solubility

H2O: 89 mg/mL

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC

InChI

1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

InChI key

QULBVRZTKPQGCR-NDAAPVSOSA-N

유전자 정보

human ... DRD2(1813)

애플리케이션

S(−)-Raclopride (+)-tartrate salt has been used as a D2 receptor antagonist:
  • to study the role of the D2 receptor in mediating ventrolateral PAG (vlPAG)/dorsal raphe dopaminergic antinociceptive effect in animals
  • in pharmacological and behavioral studies performed with Thap1 null mice
  • to determine the relationship between Ca2+ transients and dopamine neuron activity in rats

생화학적/생리학적 작용

Raclopride is a benzamide derivative and a selective D2 dopamine receptor antagonist.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

주의사항

Photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BCCL5818
BCCH7665
BCCC6896
BCBW8974
BCBS7358

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Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this study we used the dopamine D2 receptor antagonist raclopride
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질문

  1. If a stock solution of raclopride tartrate is made in PBS, can this be stored aliquoted in -20°C? If so, for how long can this be stored?

    1 답변

    1. The solubility in PBS has not been evaluated, and additional stability studies following reconstitution have not been conducted. According to the datasheet, storage should be in a tightly sealed container at room temperature, and the product is soluble in water at 89 mg/ml. More information can be found in the document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/363/806/r121dat.pdf. According to established guidelines, the stock solution should be stored as follows: at -80 °C, it is recommended to use the solution within 6 months; at -20 °C, it should be used within 1 month.

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