405210

ID-8

A cell-permeable indole compound that, when added to murine D3ES ESC (embryonic stem cell) cultures in the absence of serum and MEF (murine embryonic fibroblast) feeder cells, serves as a cheaper, chemical alternative to LIF

• 동의어(들): ID-8, 1-(4-Methoxyphenyl)-2-methyl-3-nitro-indol-6-ol
• 실험식(Hill 표기법): C₁₆H₁₄N₂O₄
• CAS Number: 147591-46-6
• Molecular Weight: 298.29
• MDL number: MFCD00593367
• UNSPSC 코드: 12352200
• NACRES: NA.51

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [N+](=O)([O-])c1c2c([n](c1C)c3ccc(cc3)OC)cc(cc2)O
• InChI: 1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
• InChI key: VVZNWYXIOADGSW-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable indole compound that, when added (10 µM) to murine D3ES ESC (embryonic stem cell) cultures in the absence of serum and MEF (murine embryonic fibroblast) feeder cells, serves as a cheaper, chemical alternative to LIF (1,000 units/ml) for expanding ESCs in their undifferentiated state. Long-term murine ESCs maintained under ID-8 are capable of differentiating and EBs (Embryoid Bodies) formation upon ID-8 removal. Also claimed to maintain human ESCs in their pluripotent state in the absence of MEF.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Miyabayashi, T., et al. 2008. Biosci. Biotechnol. Biochem.72, 1242.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3