361515
Glycogen Phosphorylase Inhibitor
The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.
동의어(들):
Glycogen Phosphorylase Inhibitor, 1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
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크기 선택
1 MG
₩197,925
₩197,925
예상 입고일2025년 5월 16일세부사항
모든 사진(1)
크기 선택
보기 변경
1 MG
₩197,925
About This Item
실험식(Hill 표기법):
C17H15ClF2N4O4
CAS Number:
Molecular Weight:
412.78
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
₩197,925
예상 입고일2025년 5월 16일세부사항
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
white
solubility
DMSO: 25 mg/mL
배송 상태
ambient
저장 온도
2-8°C
SMILES string
Fc1c(cc(c(c1)Cl)C(=O)NC(=O)Nc2c(ccc(c2)NC(=O)NC)OC)F
InChI
1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)
InChI key
ROJNYKZWTOHRNU-UHFFFAOYSA-N
일반 설명
A cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
Glycogen phosphorylase
Glycogen phosphorylase
Product does not compete with ATP.
Reversible: no
Target IC50: 53 nM against glycogen phosphorylase
포장
Packaged under inert gas
경고
Toxicity: Irritant (B)
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
기타 정보
Klabunde, T., et al. 2005. J. Med. Chem.48, 6178
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yueqin He et al.
Scientific reports, 10(1), 10180-10180 (2020-06-25)
CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in
Qian Zheng et al.
Theranostics, 11(18), 8674-8691 (2021-09-16)
Background: Clear cell renal cell carcinoma (ccRCC) is characterized by glycogen-laden, unexplained male predominance, and frequent mutations in the Von Hippel-Lindau (VHL) gene and histone modifier genes. Besides, poor survival rates of ccRCC patients seem to be associated with up-regulation
Kasandra S Hunter et al.
Frontiers in microbiology, 12, 726465-726465 (2021-09-21)
On entering the mammalian host, schistosomes transition from a freshwater environment where resources are scarce, to an environment where there is an unlimited supply of glucose, their preferred energy substrate. Adult schistosome glycolytic activity consumes almost five times the parasite's
Nont Kosaisawe et al.
Cell metabolism, 33(3), 649-665 (2021-02-10)
Cell-to-cell heterogeneity in metabolism plays an unknown role in physiology and pharmacology. To functionally characterize cellular variability in metabolism, we treated cells with inhibitors of oxidative phosphorylation (OXPHOS) and monitored their responses with live-cell reporters for ATP, ADP/ATP, or activity
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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