351801

Glucose Transporter Inhibitor III, STF-31

The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.

• 동의어(들): Glucose Transporter Inhibitor III, STF-31, STF-31
• 실험식(Hill 표기법): C₂₃H₂₅N₃O₃S
• Molecular Weight: 423.53
• MDL number: MFCD04153828
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 50 mg/mL
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• SMILES string: [S](=O)(=O)(NCc2ccc(cc2)C(=O)Nc3cnccc3)c1ccc(cc1)C(C)(C)C
• InChI key: NGQPRVWTFNBUHA-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Chan, D., et al. 2011. Sci. Transl. Med.3, 94ra70.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable