341251

Fascaplysin, Synthetic

A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 0.35 µM).

• 동의어(들): Fascaplysin, Synthetic
• 실험식(Hill 표기법): C₁₈H₁₁ClN₂O
• CAS Number: 114719-57-2
• Molecular Weight: 306.75
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (NMR)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: brown
• solubility: methanol: 1 mg/mL; DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C18H10N2O.ClH/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;/h1-10H;1H
• InChI key: PWUOOJVYZQILBG-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable red pigment, originally isolated from a species of marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 350 nM). Reported to inhibit Cdk6/cyclin D1 with much lower potency (IC₅₀ = 3.4 µM). Exhibits little to no effect on the activities of several other Cdk′s (IC₅₀ >20 µM) and tyrosine kinases (IC₅₀ >10 µM). Biological effects are attributed, in part, to its ability to intercalate into DNA. Also displays anti-microbial activity.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
CDK4/D1

Product competes with ATP.

Reversible: yes

Target IC₅₀: 0.35 µM against Cdk4/D1

포장

Packaged under inert gas

경고

Toxicity: Toxic (F)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Hormann, A., et al. 2001. Bioorg. Med. Chem.9, 917.
Kirsch, G., et al. 2000. J. Nat. Prod.63, 825.
Soni, R., et al. 2000. Biochem. Biophys. Res. Commun.275, 877.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable