220285

Chelerythrine Chloride

Naturally-occurring alkaloid.

• 동의어(들): Chelerythrine Chloride
• 실험식(Hill 표기법): C₂₁H₁₈ClNO₄
• CAS Number: 3895-92-9
• Molecular Weight: 383.82
• MDL number: MFCD00060717
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 설명: Merck USA index - 14, 2051
• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 효능: 660 nM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: light yellow to yellow
• solubility: water: 1 mg/mL; DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: [Cl-].[n+]1(c2c(c5c(c1)c(c(cc5)OC)OC)ccc3c2cc4c(c3)OCO4)C
• InChI: 1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1
• InChI key: WEEFNMFMNMASJY-UHFFFAOYSA-M

설명

일반 설명

Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC₅₀ = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.

Naturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC₅₀ = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful (C)

제조 메모

Heating to 40-50°C with gentle agitation may be necessary to achieve complete solubilization. Further dilute with buffer just prior to use.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Kandasamy, R.A., et al. 1995. J. Biol. Chem.270 29209.
Jarvis, W.D., et al. 1994. Cancer Res.54, 1707.
Barg, J., et al. 1992. J. Neurochem.59, 1145.
Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun.172, 993.
Ko, F., et al. 1990. Biochim. Biophys. Acta1052, 360.
Walterova, D., et al. J. Med. Chem.24, 1100.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302 + H312 + H332,H315,H319,H335
• 예방조치 성명서: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable