251800

Daunorubicin, Hydrochloride

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase.

• 동의어(들): Daunorubicin, Hydrochloride, Daunomycin, HCl
• 실험식(Hill 표기법): C₂₇H₂₉NO₁₀ · xHCl
• CAS Number: 23541-50-6
• Molecular Weight: 527.52 (free base basis)
• MDL number: MFCD04974507
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 양식: crystalline solid
• 효능: ≥840 g/kg
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: red
• solubility: aqueous buffer: soluble; methanol: soluble; water: soluble
• 배송 상태: ambient
• 저장 온도: 10-30°C
• InChI: 1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
• InChI key: GUGHGUXZJWAIAS-QQYBVWGSSA-N

설명

일반 설명

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis and to intercalate into DNA. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
DNA synthesis, RNA synthesis

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

재구성

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.

기타 정보

Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol.46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H341,H351,H360FD
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3