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Merck
모든 사진(4)

문서

44583

Sigma-Aldrich

Doxorubicin hydrochloride

suitable for fluorescence, 98.0-102.0% (HPLC)

동의어(들):

DOX, Hydroxydaunorubicin hydrochloride

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모든 사진(4)

About This Item

실험식(Hill 표기법):
C27H29NO11 · HCl
CAS Number:
25316-40-9
Molecular Weight:
579.98
Beilstein:
4229251
EC Number:
246-818-3
MDL number:
MFCD00077757
UNSPSC 코드:
51281818
PubChem Substance ID:
57650234
NACRES:
NA.76

생물학적 소스

synthetic

Quality Level

200

분석

98.0-102.0% (HPLC)

형태

solid

색상

orange to dark red

mp

216 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL, clear, orange to red
DMSO: soluble
THF: soluble
ethanol: soluble
methanol: soluble

형광

λem 580-590 nm

적합성

suitable for fluorescence

항생제 활성 스펙트럼

neoplastics

동작 모드

DNA synthesis | interferes
enzyme | inhibits

저장 온도

2-8°C

SMILES string

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key

MWWSFMDVAYGXBV-RUELKSSGSA-N

유전자 정보

human ... TOP2A(7153)

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관련 카테고리

일반 설명

Chemical structure: tetracycline

애플리케이션

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

생화학적/생리학적 작용

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Danger

유해 및 위험 성명서

H302,H340,H350,H360FD

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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Sigma-Aldrich

T7402

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D0125000

Daunorubicin hydrochloride

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Sigma-Aldrich

T7191

Paclitaxel

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