220467

2-Chloro-2′-deoxyadenosine

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

• 동의어(들): 2-Chloro-2′-deoxyadenosine, 2CdA, Cladribine
• 실험식(Hill 표기법): C₁₀H₁₂ClN₅O₃
• CAS Number: 4291-63-8
• Molecular Weight: 285.69
• MDL number: MFCD00153939
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: Merck USA index - 14, 2337
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: Clc1nc2[n](cnc2c(n1)N)[C@@H]3O[C@@H]([C@H](C3)O)CO
• InChI: 1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
• InChI key: PTOAARAWEBMLNO-KVQBGUIXSA-N

설명

일반 설명

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Antileukemic and immunosuppressive activity

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

기타 정보

Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H341,H361fd,H372
• 예방조치 성명서: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable