추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
saturated ammonium sulfate (SAS) precipitated
항체 생산 유형
primary antibodies
클론
polyclonal
양식
liquid
포함
≤0.1% sodium azide as preservative
종 반응성
human
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
동형
IgG
배송 상태
wet ice
저장 온도
2-8°C
타겟 번역 후 변형
unmodified
관련 카테고리
일반 설명
Anti-Cathepsin D, rabbit polyclonal, recognizes the ~50 kDa latent and the ~30 kDa active forms in breast carcinoma cell line. It is validated for ELISA, Western blotting, and immunoelectrophoresis.
Rabbit polyclonal antibody purified by ammonium sulfate precipitation. Recognizes the ~50 kDa latent and the ~30 kDa active forms of cathepsin D.
Recognizes the ~50 kDa latent and the ~30 kDa active forms of cathepsin D in breast carcinoma cell line.
면역원
Human
purified human liver cathepsin D
애플리케이션
ELISA (≥1:1000)
Immunoelectrophoresis (see comments)
Immunoelectrophoresis (see comments)
포장
Please refer to vial label for lot-specific concentration.
경고
Toxicity: Standard Handling (A)
물리적 형태
In PBS.
재구성
Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.
분석 메모
Positive Control
Human liver tissue
Human liver tissue
기타 정보
Monospecific for cathepsin D as determined by a single arc by immunoelectrophoresis against crude live extract and purified cathepsin D. Variables associated with assay conditions will dictate the proper working dilution.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Rachel Allison et al.
The Journal of cell biology, 216(5), 1337-1355 (2017-04-09)
Contacts between endosomes and the endoplasmic reticulum (ER) promote endosomal tubule fission, but the mechanisms involved and consequences of tubule fission failure are incompletely understood. We found that interaction between the microtubule-severing enzyme spastin and the ESCRT protein IST1 at
Gonzalo A Mardones et al.
Molecular biology of the cell, 18(9), 3486-3501 (2007-06-29)
The sorting of acid hydrolase precursors at the trans-Golgi network (TGN) is mediated by binding to mannose 6-phosphate receptors (MPRs) and subsequent capture of the hydrolase-MPR complexes into clathrin-coated vesicles or transport carriers (TCs) destined for delivery to endosomes. This
Maya M Polovitskaya et al.
American journal of human genetics, 107(6), 1062-1077 (2020-11-21)
Dysfunction of the endolysosomal system is often associated with neurodegenerative disease because postmitotic neurons are particularly reliant on the elimination of intracellular aggregates. Adequate function of endosomes and lysosomes requires finely tuned luminal ion homeostasis and transmembrane ion fluxes. Endolysosomal
M Heinrich et al.
Cell death and differentiation, 11(5), 550-563 (2004-01-24)
Acidic noncaspase proteases-like cathepsins have been introduced as novel mediators of apoptosis. A clear role for these proteases and the acidic endolysosomal compartment in apoptotic signalling is not yet defined. To understand the role and significance of noncaspases in promoting
Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor.
Daniel J Metcalf et al.
Traffic (Copenhagen, Denmark), 9(11), 1905-1914 (2008-09-27)
The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are a group of inherited childhood-onset neurodegenerative disorders characterized by the lysosomal accumulation of undigested material within cells. To understand this dysfunction, we analysed trafficking of the cation-independent mannose 6-phosphate receptor (CI-MPR), which
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