1.37004

Titriplex^® III

(ethylene dinitrilo tetraacetic acid disodium salt dihydrate), EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• 동의어(들): Ethylenediaminetetraacetic acid disodium salt dihydrate, Disodium dihydrogen ethylenediaminetetraacetate, Ethylenediaminetetraacetic acid disodium salt, Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na₂, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na₂
• 실험식(Hill 표기법): C₁₀H₁₄N₂Na₂O₈ · 2H₂O
• CAS Number: 6381-92-6
• Molecular Weight: 372.24
• Beilstein: 3900609
• UNSPSC 코드: 12352107
• EC 인덱스 번호: 205-358-3

속성

• Grade: ACS reagent
• Quality Level: 500
• Agency: BP; ChP; JP; Ph. Eur.; USP
• 제품 라인: EMPROVE^® EXPERT
• 양식: solid
• 특징: RNase and DNase free
• pH: 4-5 (20 °C, 50 g/L in H₂O)
• mp: 248 °C (dec.) (lit.)
• 응용 분야: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• 저장 온도: no temp limit
• SMILES string: O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
• InChI: 1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
• InChI key: OVBJJZOQPCKUOR-UHFFFAOYSA-L

설명

일반 설명

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

애플리케이션

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Titriplex^® III (EDTA, ethylene dinitrilo tetraacetic acid disodium salt dihydrate) is a commonly used chelating agent. As it is capable of forming complexes with divalent metal cations, it can inhibit diverse enzymes that require such cations for activity. It is broadly used as antioxidant in pharmaceutical formulations and cosmetics and can enhance the function of preservatives. The disodium salt provides improved solubility in water compared to standard EDTA.
Due to its low microbial and endotoxin limits, Titriplex^® III (ethylene dinitrilo tetraacetic acid disodium salt dihydrate) Emprove^® Expert is especially suitable for high-risk applications.

기타 정보

Elimination of water of crystallization: 110 °C

법적 정보

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Titriplex is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H332,H373
• 예방조치 성명서: P260 - P271 - P304 + P340 + P312 - P314 - P501
• Hazard Classifications: Acute Tox. 4 Inhalation - STOT RE 2 Inhalation
• 표적 기관: Respiratory Tract
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable