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860825P

Avanti

24:1(2R-OH) Ceramide

Avanti Research™ - A Croda Brand 860825P, powder

동의어(들):

N-(2′-(R)-hydroxynervonoyl)-D-erythro-sphingosine

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크기 선택

5 MG
₩494,508

₩494,508

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모든 사진(1)

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보기 변경
5 MG
₩494,508

About This Item

실험식(Hill 표기법):
C42H81NO4
CAS Number:
1246298-50-9
Molecular Weight:
664.10
MDL number:
MFCD22416681
UNSPSC 코드:
12352211
NACRES:
NA.25

₩494,508

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

양식

powder

포장

pkg of 1 × 5 mg (860825P-5mg)

제조업체/상표

Avanti Research™ - A Croda Brand 860825P

지질 유형

sphingolipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCC/C=C\CCCCCCCC)=O)CO

InChI

1S/C42H81NO4/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-25-27-29-31-33-35-37-41(46)42(47)43-39(38-44)40(45)36-34-32-30-28-26-24-16-14-12-10-8-6-4-2/h17-18,34,36,39-41,44-46H,3-16,19-33,35,37-38H2,1-2H3,(H,43,47)/b18-17-,36-34+/t39-,40+,41+/m0/s1

InChI key

AEJPDHWODCHVKB-LDVUWZDOSA-N

일반 설명

Ceramides containing 2-hydroxy fatty acids (hFA) are mainly found in the epidermis.[1] 24:1(2R-OH) Ceramide is a 2R hydroxylated nervonic acid-containing sphingolipid.[2]

생화학적/생리학적 작용

Hydroxy fatty acid (hFA)-sphingolipids play a vital role in cell signaling,[3] cell differentiation and apoptosis.[2] These lipids also aid in formation and function of myelin.[4] hFA-ceramide is produced by NAD(P)H-dependent enzyme, fatty acid 2-hydroxylase (FA2H).[5] hFA-ceramides help in epidermal permeability barrier function.[3]

포장

5 mL Amber Glass Screw Cap Vial (860825P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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시험 성적서(COA)

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문서 라이브러리 방문

Inge Zöller et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(39), 9741-9754 (2008-09-26)
Sphingolipids containing 2-hydroxylated fatty acids are among the most abundant lipid components of the myelin sheath and therefore are thought to play an important role in formation and function of myelin. To prove this hypothesis, we generated mice lacking a
Helena Maier et al.
The Journal of biological chemistry, 286(29), 25922-25934 (2011-06-02)
2-Hydroxylated fatty acid (HFA)-containing sphingolipids are abundant in mammalian skin and are believed to play a role in the formation of the epidermal barrier. Fatty acid 2-hydroxylase (FA2H), required for the synthesis of 2-hydroxylated sphingolipids in various organs, is highly
Lin Guo et al.
Journal of lipid research, 53(7), 1327-1335 (2012-04-21)
FA 2-hydroxylase (FA2H) is an NAD(P)H-dependent enzyme that initiates FA α oxidation and is also responsible for the biosynthesis of 2-hydroxy FA (2-OH FA)-containing sphingolipids in mammalian cells. The 2-OH FA is chiral due to the asymmetric carbon bearing the
Nathan L Alderson et al.
Journal of lipid research, 50(6), 1203-1208 (2009-01-28)
Sphingolipids are ubiquitous components of eukaryotic cells that regulate various cellular functions. In many cell types, a fraction of sphingolipids contain 2-hydroxy fatty acids, produced by fatty acid 2-hydroxylase (FA2H), as the N-acyl chain of ceramide [hydroxyl fatty acid (hFA)-sphingolipids].
Ana B Herrero et al.
Cancer research, 68(23), 9779-9787 (2008-12-03)
PM02734 is a novel synthetic antitumor drug that is currently in phase I clinical trials. To gain some insight into its mode of action, we used the yeast Saccharomyces cerevisiae as a model system. Treatment of S. cerevisiae with PM02734
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