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Merck
모든 사진(1)

문서

860823P

Avanti

24:0(2R-OH) Ceramide

Avanti Research - A Croda Brand 860823P, powder

동의어(들):

N-(2′-(R)-hydroxylignoceroyl)-D-erythro-sphingosine

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About This Item

실험식(Hill 표기법):
C42H83NO4
CAS Number:
Molecular Weight:
666.11
UNSPSC 코드:
12352211
NACRES:
NA.25

형태

powder

포장

pkg of 1 × 5 mg (860823P-5mg)

제조업체/상표

Avanti Research - A Croda Brand 860823P

지질 유형

sphingolipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCCCCCCCCCC)=O)CO

일반 설명

Ceramides containing 2-hydroxy fatty acids (hFA) are present in the surface epithelium of the skin. 24:0(2R-OH) Ceramide is a 2R hydroxylated lignoceric acid -containing sphingolipid. hFA-ceramides are synthesized by the enzyme fatty acid 2-hydroxylase (FA2H). hFA-ceramides aid in epidermal permeability barrier function.

포장

5 mL Amber Glass Screw Cap Vial (860823P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


시험 성적서(COA)

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문서 라이브러리 방문

Andrej Kováčik et al.
Langmuir : the ACS journal of surfaces and colloids, 33(11), 2890-2899 (2017-02-24)
Ceramides (Cer) based on 6-hydroxysphingosine are important components of the human skin barrier, the stratum corneum. Although diminished concentrations of 6-hydroxyCer have been detected in skin diseases such as atopic dermatitis, our knowledge on these unusual sphingolipids, which have only
Daniel A Peñalva et al.
Biochimica et biophysica acta, 1838(3), 731-738 (2013-12-10)
Unique species of ceramide (Cer) with very-long-chain polyunsaturated fatty acid (VLCPUFA), mainly 28-32 carbon atoms, 4-5 double bonds, in nonhydroxy and 2-hydroxy forms (n-V Cer and h-V Cer, respectively), are generated in rat spermatozoa from the corresponding sphingomyelins during the
Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands
Maier H, et al.
The Journal of Biological Chemistry, 286(29), 25922-25934 (2011)
Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers
Guo L, et al.
Journal of Lipid Research, 53(7), 1327-1335 (2012)
Helena Maier et al.
The Journal of biological chemistry, 286(29), 25922-25934 (2011-06-02)
2-Hydroxylated fatty acid (HFA)-containing sphingolipids are abundant in mammalian skin and are believed to play a role in the formation of the epidermal barrier. Fatty acid 2-hydroxylase (FA2H), required for the synthesis of 2-hydroxylated sphingolipids in various organs, is highly

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