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860822P

Avanti

22:0(2S-OH) Ceramide

Avanti Research™ - A Croda Brand 860822P, powder

동의어(들):

N-(2′-(S)-hydroxybehenoyl)-D-erythro-sphingosine

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크기 선택

5 MG
₩524,248

₩524,248

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모든 사진(1)

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보기 변경
5 MG
₩524,248

About This Item

실험식(Hill 표기법):
C40H79NO4
CAS Number:
1246298-49-6
Molecular Weight:
638.06
MDL number:
MFCD22416678
UNSPSC 코드:
12352211
NACRES:
NA.25

₩524,248

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

양식

powder

포장

pkg of 1 × 5 mg (860822P-5mg)

제조업체/상표

Avanti Research™ - A Croda Brand 860822P

지질 유형

sphingolipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCCCCCCCCCCCC)=O)CO

InChI

1S/C40H79NO4/c1-3-5-7-9-11-13-15-17-18-19-20-21-23-25-27-29-31-33-35-39(44)40(45)41-37(36-42)38(43)34-32-30-28-26-24-22-16-14-12-10-8-6-4-2/h32,34,37-39,42-44H,3-31,33,35-36H2,1-2H3,(H,41,45)/b34-32+/t37-,38+,39-/m0/s1

InChI key

FCCZDEAAQZWMGI-RHJYVNCBSA-N

일반 설명

Ceramides containing 2-hydroxy fatty acids (hFA) are primarily found in the epidermis.[1] 22:0(2S-OH) Ceramide is a 2S hydroxylated behenic acid-containing sphingolipid.[2]

생화학적/생리학적 작용

Sphingolipids containing hydroxy fatty acid (hFA) are implicated in cell signaling,[3] cell differentiation and apoptosis.[2] These lipids, which are found majorly in myelin sheath helps in formation and function of myelin.[4] NAD(P)H-dependent enzyme, fatty acid 2-hydroxylase (FA2H) catalyzes the synthesis of hFA-ceramide.[5] hFA-ceramides aid in epidermal permeability barrier function.[3]

포장

5 mL Amber Glass Screw Cap Vial (860822P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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시험 성적서(COA)

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문서 라이브러리 방문

Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration
Zoller I, et al.
The Journal of Neuroscience, 28(39), 9741-9754 (2008)
Inge Zöller et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(39), 9741-9754 (2008-09-26)
Sphingolipids containing 2-hydroxylated fatty acids are among the most abundant lipid components of the myelin sheath and therefore are thought to play an important role in formation and function of myelin. To prove this hypothesis, we generated mice lacking a
Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers
Guo L, et al.
Journal of Lipid Research, 53(7), 1327-1335 (2012)
Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands
Maier H, et al.
The Journal of Biological Chemistry, 286(29), 25922-25934 (2011)
Helena Maier et al.
The Journal of biological chemistry, 286(29), 25922-25934 (2011-06-02)
2-Hydroxylated fatty acid (HFA)-containing sphingolipids are abundant in mammalian skin and are believed to play a role in the formation of the epidermal barrier. Fatty acid 2-hydroxylase (FA2H), required for the synthesis of 2-hydroxylated sphingolipids in various organs, is highly
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