860815P

16:0(2R-OH) Ceramide

Avanti Research^™ - A Croda Brand 860815P, powder

• 동의어(들): N-(2′-(R)-hydroxypalmitoyl)-D-erythro-sphingosine
• 실험식(Hill 표기법): C₃₄H₆₇NO₄
• CAS Number: 34839-02-6
• Molecular Weight: 553.90
• MDL number: MFCD22416671
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 양식: powder
• 포장: pkg of 1 × 25 mg (860815P-25mg); pkg of 1 × 5 mg (860815P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 860815P
• 지질 유형: sphingolipids
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO
• InChI key: YWZGQPJRQXHVQX-GGMPIESISA-N

설명

일반 설명

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis.[1] 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.[2]

생화학적/생리학적 작용

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling.[3] They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide.[2] hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans.[3] The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.[4]

포장

5 mL Amber Glass Screw Cap Vial (860815P-25mg)

5 mL Amber Glass Screw Cap Vial (860815P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3