추천 제품
양식
powder
포장
pkg of 1 × 5 mg (860502P-5mg)
제조업체/상표
Avanti Research™ - A Croda Brand 860502P
지질 유형
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
OC[C@]([H])(NC(C)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C20H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h15-16,19-20,22,24H,3-14,17H2,1-2H3,(H,21,23)/b16-15+/t19-,20+/m0/s1
InChI key
BLTCBVOJNNKFKC-QUDYQQOWSA-N
일반 설명
C2 Ceramide (d18:1/2:0) is a short-chain ceramide. In general ceramides are synthesized by de novo pathway from palmitic acid via series of intermediates to ceramidein the presence of dihydroceramide Δ4-desaturase.[1]
애플리케이션
C2 Ceramide (d18:1/2:0) has been used to treat protoplasts for reactive oxygen species generation[2] and as an substrate for sphingomyelin synthase 2 enzyme.[3] It is suitable for use as an exogenous supplement in hippocampal cell cultures for the production of 2-hydroxyeicosatetraenoic acid (12-(S)-HETE).[4]
생화학적/생리학적 작용
C2 ceramide inhibits the progression of human bronchocarcinoma by modulating the matrix metallopeptidases-2 levels. It also inhibits glioma invasion[5] and induces apoptosis in HT-29 and HCT-116 human colon cancer cells.[6] Treatment of myotubes with C2-ceramide leads to decrease in glucose uptake and glycogen synthesis.[1] C2 along with C6 ceramides induces insulin resistance in myoblastic C2C12 cell line and L6 myotubes.[7]
포장
5 mL Amber Glass Screw Cap Vial (860502P-5mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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이미 열람한 고객
Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes
Prasad VVTS, et al.
Neurochemistry International, 53(6-8), 220-229 (2008)
Induction of apoptosis by sphingosine, sphinganine, and C2-ceramide in human colon cancer cells, but not by C2-dihydroceramide
Ahn EH and Schroeder JJ
Anticancer research, 30(7), 2881-2884 (2010)
Exogenous C2 ceramide suppresses matrix metalloproteinase gene expression by inhibiting ROS production and MAPK signaling pathways in PMA-stimulated human astroglioma cells
Jung JS, et al.
International Journal of Molecular Sciences, 17(4), 477-477 (2016)
Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
Bandet C, et al.
International Journal of Molecular Sciences, 20(3), 479-479 (2019)
Ceramide and insulin resistance: how should the issue be approached?
Gorski J
Diabetes, 61(12), 3081-3083 (2012)
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