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857392O

Avanti

(R)-FTY720-OMe

(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol, neat oil

동의어(들):

(R)-FTY720-methyl ether; ROME

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크기 선택

1 MG
₩291,102

₩291,102

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(2)

크기 선택

보기 변경
1 MG
₩291,102

About This Item

실험식(Hill 표기법):
C20H35NO2
CAS Number:
1382486-90-9
Molecular Weight:
321.50
MDL number:
MFCD16621009
UNSPSC 코드:
12352211
NACRES:
NA.25

₩291,102

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

분석

>99% (TLC)

양식

liquid

포장

pkg of 1 × 1 mg (857392O-1mg)

제조업체/상표

Avanti Research™ - A Croda Brand 857392O

지질 유형

sphingolipids
bioactive lipids

배송 상태

dry ice

저장 온도

−20°C

일반 설명

(R)-FTY720-OMe is the analogue of FTY720.[1]
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.

생화학적/생리학적 작용

(R)-FTY720-OMe helps to block DNA synthesis and actin rearrangement induced by sphingosine 1-phosphate (S1P) in MCF-7 breast cancer cells. It can also reduce sphingosine kinase 2 (SK2) expression and prevent DNA synthesis in HEK 293 cells. (R)-FTY720-OMe has anti-breast cancer potential.[1]

포장

5 mL Amber Glass Screw Cap Vial (857392O-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

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시험 성적서(COA)

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문서 라이브러리 방문

(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells
Lim KG, et al.
Cellular Signalling, 23(10), 1590-1595 (2011)
David G Watson et al.
Cellular signalling, 25(4), 1011-1017 (2013-01-15)
Two isoforms of sphingosine kinase, SK1 and SK2, catalyze the formation of the bioactive lipid sphingosine 1-phosphate (S1P) in mammalian cells. We have previously shown that treatment of androgen-sensitive LNCaP prostate cancer cells with a non-selective SK isoform inhibitor, 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole
Keng Gat Lim et al.
Cellular signalling, 23(10), 1590-1595 (2011-05-31)
Sphingosine kinase 2 (SK2) catalyses the conversion of sphingosine to the bioactive lipid sphingosine 1-phosphate (S1P). We report here, the stereospecific synthesis of an analogue of FTY720 called (R)-FTY720-OMe, which we show is a competitive inhibitor of SK2. (R)-FTY720-OMe failed
Francesca Tonelli et al.
British journal of pharmacology, 168(6), 1497-1505 (2012-11-02)
Sphingosine kinase catalyses the formation of sphingosine 1-phosphate and is linked with androgen receptor signalling in prostate cancer cells. Therefore, we investigated the effect of sphingosine kinase inhibitors on androgen receptor expression. Androgen-sensitive LNCaP cells were treated with SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole)

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