추천 제품
분석
>99% (TLC)
형태
powder
분자량
322.91 g/mol
포장
pkg of 1 × 25 mg (850546P-25mg)
제조업체/상표
Avanti Research™ - A Croda Brand 850546P
배송 상태
dry ice
저장 온도
−20°C
SMILES string
[NH3+][C@@H](COC)C(NCCCCCCCCCCCC)=O.[Cl-]
일반 설명
O-methyl-serine-dodecylamide hydrochloride (MSDH) is a synthetic lysosomotropic detergent.
애플리케이션
MSDH is suitable is suitable to induce lysosomal membrane destabilization to investigate the mechanistic basis for Bax/Bak-mediated autophagic cell death.
생화학적/생리학적 작용
O-methyl-serine-dodecylamide hydrochloride (MSDH) stimulates cell death. After apoptosis, it may activate procaspase 3-like proteases and cause partial lysosomal rupture.
포장
5 mL Amber Glass Screw Cap Vial (850546P-25mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Langmuir : the ACS journal of surfaces and colloids, 32(50), 13566-13575 (2016-12-13)
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in
Methylmercury and H2O2 provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
Free radical biology & medicine, 30(12), 1347-1356 (2001)
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
eLife, 6, e30543-e30543 (2017)
Induction of cell death by the lysosomotropic detergent MSDH
Febs Letters, 470(1), 35-39 (2000)
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
Journal of Hepatology, 61(5), 1126-1134 (2014)
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