710337C

14:1 Cardiolipin

Avanti Research^™ - A Croda Brand 710337C

• 동의어(들): 1′,3′-bis[1,2-dimyristoleoyl-sn-glycero-3-phospho]-glycerol (sodium salt)
• 실험식(Hill 표기법): C₆₅H₁₁₆Na₂O₁₇P₂
• CAS Number: 2260669-33-6
• Molecular Weight: 1277.53
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: liquid
• 포장: pkg of 1 × 1 mL (710337C-5mg); pkg of 1 × 2.5 mL (710337C-25mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 710337C
• 농도: 10 mg/mL (710337C-25mg); 5 mg/mL (710337C-5mg)
• 지질 유형: phospholipids; cardiolipins
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: O=P([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O)=O.[Na+].[Na+]
• InChI key: KMIXSFXJUMNKKR-IVOFNDPZSA-L

설명

일반 설명

3β,7α-dihydroxy-5-cholestenoic acid is a sterol derived from cholestenoic acid.

Cardiolipin is an anionic phospholipid containing four acyl chains and small headgroup.[1]

Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. It is an important component of ATP synthase enzyme.[2]

애플리케이션

14:1 Cardiolipin may be used as reference standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS).[3] It may also be used in the quantification of mitochondrial phospholipids[4] and yeast respiratory chain complex[5] using mass spectrometry.

생화학적/생리학적 작용

Cardiolipin and cytochrome c interaction determines the function of proteins involved in oxidative phosphorylation and apoptosis.[6] Cardiolipin involved in proton uptake pathway maintains the structure of enzymes participating.[1] Cardiolipin controls the mitochondrial function and membrane potential. It offers structural support for the inner mitochondrial membrane and proteins in it. Altered cardiolipin concentration and composition have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy.

TMCL (1,1′,2,2′-tetramyristoyl cardiolipin) bilayers are useful in generating multilamellar vesicles. Defects in the metabolic pathway of cardiolipin is associated with Barth syndrome patients.[2] Liposomes of TMCL with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and cholesterol are potential drug-delivery systems.[7] TMCL displays temperature dependant thermotropic phase transitions.[8]

포장

5 mL Clear Glass Sealed Ampule (710337C-25mg)

5 mL Clear Glass Sealed Ampule (710337C-5mg)

ST503: 3 Vial/Ampule Tray with Outer Cardboard Box (3-1/8" x 29/32" x 2-15/16") (710337C-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• 예방조치 성명서: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• 표적 기관: Central nervous system, Liver,Kidney
• WGK: WGK 3