700026P

3β-hydroxy-7-oxo-5-cholestenoic acid

Avanti Research^™ - A Croda Brand

• 동의어(들): (25R)-cholest-5-en-26-oic acid, 3β-hydroxy-7-oxo
• 실험식(Hill 표기법): C₂₇H₄₂O₄
• CAS Number: 1246298-64-5
• Molecular Weight: 430.62
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 형태: powder
• 포장: pkg of 1 × 5 mg (700026P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 배송 상태: dry ice
• 저장 온도: −20°C

설명

일반 설명

Cholestenoic acids are cholesterol metabolic intermediates and precursors to bile acids. 3β-hydroxy-7-oxo-5-cholestenoic acid is synthesized from 7β-hydroxycholesterol. The enzymes for synthesis of cholestenoic acids are majorly present in the central nervous system (CNS) of mammals. 3β-hydroxy-7-oxo-5-cholestenoic acid (3βH,7O-CA) is also synthesized from 26-hydroxy-7-oxocholesterol by the action of the enzyme cytochrome P450 family 27 subfamily A member 1 sterol 27-hydroxylase (CYP27A1).

생화학적/생리학적 작용

3β-hydroxy-7-oxocholest-5-en-26-oic acid (3βH,7O-CA) acts as a ligand for liver X receptors (LXR) and activates them at micromolar concentration. 3βH,7O-CA favors the islet-1⁺ cells synthesis and islet-1–GFP expression. 3βH,7O-CA also mediates oculomotor neurons maturation and its conversion to 3β,7β-dihydroxycholest-5-en-(25S)26-oic acid (3β,7β-diHCA) is catalyzed by the enzyme hydroxysteroid 11-β dehydrogenase.

포장

5 mL Amber Glass Screw Cap Vial (700026P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids