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Merck
모든 사진(2)

주요 문서

699200P

Avanti

Lipid A - Purified

Avanti Research - A Croda Brand

동의어(들):

Lipid A Detoxified (Salmonella minnesotaR595)

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About This Item

CAS Number:
UNSPSC 코드:
12352211
699200P 제품과 관련한 질문은 현지 머크 영업소 또는 판매 사원에게 문의해 주십시오. 고객지원팀으로 연락바랍니다.

분석

>99% (HPLC)

양식

powder

포장

pkg of 1 × 1 mg (699200P-1mg)
pkg of 1 × 5 mg (699200P-5mg)

제조업체/상표

Avanti Research - A Croda Brand

배송 상태

dry ice

저장 온도

−20°C

SMILES string

O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](O)CCCCCCCCCCC)=O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2OC(C[C@H](O)CCCCCCCCCCC)=O.[NH4+]

일반 설명

Monophosphoryl lipid A (MPLA) is produced by hydrolysis of endotoxin lipopolysaccharide (LPS) isolated from Salmonella minnesota R595. MPLA is purified from the hydrolysate and contains a mixture of structural analogs containing differing numbers of fatty acids and positional isomers.
Purified Lipid A (MPLA) is soluble in DMSO at ~1mg/mL. Alternatively, it has been reported that MPLA can be suspended at ~1mg/mL in water or isotonic saline containing 0.2% triethylamine. After adding water/saline containing triethylamine to the MPLA powder, swirl the suspension in 65-70°C water bath for 10-20 seconds, then disperse by sonication using an ultrasonic bath for 30 seconds. The final solution will be slightly turbid.

애플리케이션

Lipid A - purified has been used as an adjuvant in the reconstitution lipid mixture.[1]
Lipid A- purified has been used for toll-like receptor (TLR) ligand treatment.[2]

생화학적/생리학적 작용

Detoxified monophosphoryl lipid A (MPLA) acts as a toll-like receptor 4 (TLR4) agonist. Hydrolysis of the lipopolysaccharide (LPS) to yield MPLA, retains the action of stimulating the adaptive immune response while eliminating many of the pro-inflammatory side effects experienced with LPS.

포장

2 mL Amber Glass Crimp Cap Vial (699200P-1mg)
2 mL Amber Glass Crimp Cap Vial (699200P-5mg)

기타 정보

For R&D use only. Not for drug, household, or other uses.

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids


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문서 라이브러리 방문

Assay development for image-based quantification of intracellular bacterial replication and analysis of the innate immune response to infection
Miller AH, et al.
Assay and Drug Development Technologies, 13(9), 515-528 (2015)
A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic beta-cells
Merriman C, et al.
The Journal of Biological Chemistry, 293(2), 579-587 (2018)

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