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L4395

Sigma-Aldrich

Liposome Kit: Lipid mixtures for the preparation of liposomes

lyophilized powder

동의어(들):

cholesterol, L-α-phosphatidylcholine and stearylamine kit

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크기 선택

1 VIAL
₩271,208
5 VIALS
₩977,953

₩271,208

예상 입고일2025년 4월 14일세부사항

벌크 견적 요청
모든 사진(1)

크기 선택

보기 변경
1 VIAL
₩271,208
5 VIALS
₩977,953

About This Item

EC Number:
204-695-3
UNSPSC 코드:
12352211
NACRES:
NA.25

₩271,208

예상 입고일2025년 4월 14일세부사항

벌크 견적 요청

생물학적 소스

egg yolk

Quality Level

200

양식

lyophilized powder

구성

Cholesterol, 9 μmol/package
L-α-Phosphatidylcholine (egg yolk), 63 μmol/package
Stearylamine, 18 μmol/package

작용기

carboxylic acid

배송 상태

ambient

저장 온도

−20°C

관련 카테고리

애플리케이션

Liposome Kit has been used for the preparation of liposomes.[1][2][3]

생화학적/생리학적 작용

Liposome Kit: Lipid mixtures for the preparation of liposomes contains cholesterol; L-α-phosphatidylcholine and stearylamine. Liposome kit may be used to prepare cationic (positively charge) liposomes for incorporation of materials into cells.
Liposomes can be used for different applications such as drug delivery, diagnostics, membrane models, adjuvants for vaccination and others. This lipid mixture can be used to encapsulate a broad spectrum of hydrophilic and amphipathic molecules of low, medium, and high molecular weight (including peptides, proteins, and oligo- and polynucleotides).

관련 제품

제품 번호
설명
가격

픽토그램

CorrosionEnvironment
GHS05,GHS09

신호어

Danger

유해 및 위험 성명서

H318,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000418690
0000404712
0000404712
0000418690
0000408426

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Rui Xu et al.
Analytical chemistry, 88(21), 10390-10394 (2016-11-02)
Chemical analysis of small extracellular vesicles (sEVs) circulating in body fluids holds potentials in noninvasive diagnosis of diseases and evaluation of therapeutic treatments. However, quantification of sEVs remains a challenge due to lacking of cost-effective analytical protocols. Herein we report
Quantification of small extracellular vesicles by size exclusion chromatography with fluorescence detection
Xu R, et al.
Analytical Chemistry, 88(21), 10390-10394 (2016)
Evaluation of intracellular and extracellular trehalose as a cryoprotectant of stem cells obtained from umbilical cord blood
Motta JPR, et al.
Cryobiology, 68(3), 343-348 (2014)
Inhibition of cationic liposomes of [3H]thymidine incorporation into DNA of L1210 cells.
Laurent G, Laduron C, Ruysschaert JM, et al.
Research Communications in Molecular Pathology and Pharmacology, 31, 515-527 (1981)
S Palakurthi et al.
International journal of pharmaceutics, 290(1-2), 55-62 (2005-01-25)
Conventional lipid microspheres (LM) were prepared using soybean oil and lipid at a 5.5:1 weight ratio with lipid phase consisting of PC (phosphatidyl choline):CH (cholesterol) (1:0.5) by molar ratio. The average diameter of the particles was 150 nm. Long-circulating microspheres
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질문

1–7 / 7 질문  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 답변

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How do I prepare the Product L4395, Liposome Kit liposomes?

    1 답변

    1. Refer to the product information sheet (under Documents, above) for L4031 for preparation information.

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  4. What is the Department of Transportation shipping information for this product?

    1 답변

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  5. I'm thinking of purchasing Product L4395, Liposome Kit.  Why would one use positive vs. negative liposomes?

    1 답변

    1. Analogous to poly-L-lysine, one may need positively charged agents to deliver drugs to cells, hence positive liposomes.

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  6. I have purchased Product L4395, Liposome Kit.  Is there a difference between positive and negative liposomes?

    1 답변

    1. The choice is dependent upon what is being encapsulated and how it is being used.  A good reference discussing this question is Ogiso, T., et al., Effect of positively and negatively charged liposomes on skin permeation of drugs. J. Drug Target, 9(1), 49-59 (2001).

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  7. How is Product L4395, Liposome Kit, used?

    1 답변

    1. The Liposomes of a large multilamellar structure type are the most widely used. They can be prepared using Sigma liposome mixtures by concentrating an organic solvent solution of lipids to a thin film on the walls of a container such as by rotary evaporation or by drying in glass with a stream of nitrogen gas. Then, under appropriate conditions, an aqueous solution is added to the thin film and with agitation multilamellar vesicles should form spontaneously with little effort. Large or small unilamellar structured liposomes can also be prepared by varying procedure or conditions. Please see the product insert for Product No. L4031 (the link below) for a step by step protocol that will work for this product also.

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