QBD10374

SPDP-dPEG^®₄-NHS ester

• 동의어(들): 2,5-Dioxo-1-pyrrolidinyl 17-oxo-19-(2-pyridinyldithio)-4,7,10,13-tetraoxa-16-azanonadecanoate
• 실험식(Hill 표기법): C₂₃H₃₃N₃O₉S₂
• CAS Number: 1334177-95-5
• Molecular Weight: 559.65
• MDL number: MFCD13185001
• UNSPSC 코드: 12352108
• PubChem Substance ID: 329823921
• NACRES: NA.22

속성

• 분석: >90%
• 양식: solid or viscous liquid
• 반응 적합성: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• 작용기: NHS ester
• 폴리머 구조: shape: linear; functionality: heterobifunctional
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCSSC2=NC=CC=C2
• InChI: 1S/C23H33N3O9S2/c27-19(7-18-36-37-20-3-1-2-8-25-20)24-9-11-32-13-15-34-17-16-33-14-12-31-10-6-23(30)35-26-21(28)4-5-22(26)29/h1-3,8H,4-7,9-18H2,(H,24,27)
• InChI key: QTVBGVZVUCIFAH-UHFFFAOYSA-N

설명

특징 및 장점

SPDP-dPEG^®₄-NHS ester has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. Protein aggregation and precipitation also are greatly reduced with SPDP-dPEG crosslinkers compared to crosslinkers that have only hydrocarbon spacers. dPEG spacer of specific length (23.1 Å) provides precise distance control between the SPDP moiety and the target molecule. Pyridyldithiol reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT). Crosslinking experiments with SPDP reagents are not limited to those involving proteins. Any of a variety of molecules with primary amines and sulfhydryl groups can be modified or crosslinked using SPDP reagents.

법적 정보

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable