923273

2-((3aR,7aR)-1-(tert-Butoxycarbonyl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)thiazole-4-carboxylic acid

• 동의어(들): Rigid linker for PROTAC^® development
• 실험식(Hill 표기법): C₁₆H₂₃N₃O₄S
• Molecular Weight: 353.44
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• 양식: powder
• Quality Level: 100
• 반응 적합성: reagent type: linker
• 작용기: Boc; carboxylic acid
• 저장 온도: 2-8°C
• SMILES string: [H][C@]12[C@](N(C(OC(C)(C)C)=O)CC2)([H])CN(C3=NC(C(O)=O)=CS3)CC1
• InChI: 1S/C16H23N3O4S/c1-16(2,3)23-15(22)19-7-5-10-4-6-18(8-12(10)19)14-17-11(9-24-14)13(20)21/h9-10,12H,4-8H2,1-3H3,(H,20,21)/t10-,12-/m0/s1
• InChI key: JQJPLRYBMMRMOU-JQWIXIFHSA-N

설명

애플리케이션

2-((3aR,7aR)-1-(tert-Butoxycarbonyl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)thiazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:

923281

923303

기타 정보

Protein Degrader Building Blocks


Crosslinkers for Bioconjugation


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable