920665

2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid

• 동의어(들): Rigid linker for PROTAC^® development
• 실험식(Hill 표기법): C₁₅H₂₃N₃O₄
• CAS Number: 1781095-18-8
• Molecular Weight: 309.36
• MDL number: MFCD34602229
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• 반응 적합성: reagent type: linker
• Quality Level: 100
• 작용기: Boc; carboxylic acid
• SMILES string: CC(C)(OC(N1CCCC(N2C=C(C=N2)CC(O)=O)C1)=O)C
• InChI: 1S/C15H23N3O4/c1-15(2,3)22-14(21)17-6-4-5-12(10-17)18-9-11(8-16-18)7-13(19)20/h8-9,12H,4-7,10H2,1-3H3,(H,19,20)
• InChI key: XJTDXDGKXHCYGD-UHFFFAOYSA-N

설명

애플리케이션

2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920533
920649
920673
920703

기타 정보

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Practum is a registered trademark of Sartorius Lab Instruments GmbH & Co. KG

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable