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주요 문서

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803774

Sigma-Aldrich

Colby trifluoromethylation reagent

동의어(들):

Hexafluoroacetone hydrate-1,8-diazo-bicyclo[5.4.0]undec-7-ene salt

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모든 사진(3)

About This Item

실험식(Hill 표기법):
C12H18F6N2O2
CAS Number:
1400691-55-5
Molecular Weight:
336.27
UNSPSC 코드:
12352101

양식

solid

SMILES string

OC([O-])(C(F)(F)F)C(F)(F)F.C1CCC2=[N+](CC1)CCCN2

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일반 설명

Colby trifluoromethylation reagent is an amidinate salt of hexafluoroacetone hydrate. This reagent can be prepared from the ethereal solution of hexafluoroacetone trihydrate. It undergoes various trifluoromethylation reactions with electrophiles under different reaction conditions to afford trifluoromethylated products.[1]

애플리케이션

Colby trifluoromethylation reagent may be used for the preparation of fluorinated organic compounds.[1]
The Colby Trifluoromethylation Reagent is an air-stable, white solid, which can be used as a source of fluoroform through the release of trifluoroacetate. This reagent can add trifluoromethyl groups in a nucleophlic fashion to carbonyls and sulfides.

기타 정보

Amidinate Salt of Hexafluoroacetone Hydrate for the Preparation of Fluorinated Compounds by the Release of Trifluoroacetate

관련 제품

제품 번호
설명
가격

픽토그램

CorrosionExclamation mark
GHS05,GHS07

신호어

Danger

유해 및 위험 성명서

H302,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Mark V Riofski et al.
Organic letters, 15(1), 208-211 (2012-12-18)
A powerful, new reagent, an amidinate salt of hexafluoroacetone hydrate, is an air-stable salt that can be used for the preparation of fluorinated organic molecules. Nucleophilic trifluoromethylation reactions are demonstrated following the base-promoted release of trifluoroacetate. This reagent is soluble

관련 콘텐츠

Colby Group – Professor Product Portal

Prof. David Colby's laboratory is developing synthetic methods to enable the efficient modification of complex molecules, such as natural products, as well as the production of fluorinated compounds. They have focused on understanding how to cleave bonds in order to remodel structures, and their first major discovery is that the release of trifluoroacetate is a powerful approach to break carbon–carbon bonds. This strategy has enabled the invention of new reagents and methods for the synthesis of fluorinated products for drug discovery and for exploring medicinal chemistry.

질문

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활성 필터

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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