472611

(1,3-Dioxolan-2-ylmethyl)magnesium bromide solution

0.5 M in THF

• 동의어(들): 2-[(Bromomagnesio)methyl]-1,3-dioxolane, Bromo(1,3-dioxolan-2-ylmethyl)magnesium
• 실험식(Hill 표기법): C₄H₇BrMgO₂
• CAS Number: 180675-22-3
• Molecular Weight: 191.31
• MDL number: MFCD01321271
• UNSPSC 코드: 12352103
• PubChem Substance ID: 24870813
• NACRES: NA.22

속성

• 반응 적합성: reaction type: Grignard Reaction
• 농도: 0.5 M in THF
• bp: 65-67 °C
• density: 0.938 g/mL at 25 °C
• SMILES string: Br[Mg]CC1OCCO1
• InChI: 1S/C4H7O2.BrH.Mg/c1-4-5-2-3-6-4;;/h4H,1-3H2;1H;/q;;+1/p-1
• InChI key: ZDNTZRAFJZERSL-UHFFFAOYSA-M

설명

애플리케이션

(1,3-Dioxolan-2-ylmethyl)magnesium bromide is a Grignard reagent that can be used to prepare:

• 3-[¹¹C]-Propionaldehyde, a key intermediate for the synthesis of radiolabeled compound [¹¹C]SN-38, wherein SN-38 is 7-ethyl-10-hydroxy camptothecin.
• 1-[(S)-2,2-Dimethyl-(1,3)-dioxolan-4-yl]-4-(1,3-dioxolan2-yl)-2-ol by reacting with D-glyceraldehyde, which is further used to synthesize unsaturated nucleosides.
• A bicyclo carboxylate intermediate, which is employed in the total synthesis of spirovibsanin A.

안전성 정보

• 픽토그램: GHS02,GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H302,H314,H335,H336,H351
• 예방조치 성명서: P201 - P210 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• 표적 기관: Central nervous system, Respiratory system
• 보충제 위험성: EUH018,EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point (°F): 1.4 °F - closed cup
• Flash Point (°C): -17 °C - closed cup
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter