349720
(3-Carboxypropyl)triphenylphosphonium bromide
98%
동의어(들):
(4-Hydroxy-4-oxobutyl)triphenylphosphonium bromide
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모든 사진(1)
크기 선택
보기 변경
25 G
₩210,511
100 G
₩353,525
About This Item
Linear Formula:
HO2C(CH2)3P(C6H5)3Br
CAS Number:
Molecular Weight:
429.29
MDL number:
UNSPSC 코드:
12352002
PubChem Substance ID:
NACRES:
NA.22
추천 제품
![[3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide 97%](/deepweb/assets/sigmaaldrich/product/structures/101/490/c9797f74-da99-4610-8812-8572dc35c41d/640/c9797f74-da99-4610-8812-8572dc35c41d.png)
분석
98%
반응 적합성
reaction type: C-C Bond Formation
mp
244-247 °C (lit.)
작용기
carboxylic acid
phosphine
SMILES string
[Br-].OC(=O)CCC[P+](c1ccccc1)(c2ccccc2)c3ccccc3
InChI
1S/C22H21O2P.BrH/c23-22(24)17-10-18-25(19-11-4-1-5-12-19,20-13-6-2-7-14-20)21-15-8-3-9-16-21;/h1-9,11-16H,10,17-18H2;1H
InChI key
NKVJKVMGJABKHV-UHFFFAOYSA-N
애플리케이션
Reactant for preparation of:
- Piperamide analogs as histone deacetylase (HDAC) inhibitors with antitumor activity
- Boron-containing benzoxaboroles as antimalarial agents
- Methyl alkenyl quinolones as antimycobacterial agents
- Solandelactone E via Sharpless epoxidation, Taber cyclopropanation, chemoselective reductions and lithiation-borylation-allylation sequence
- Organotin compounds as antifungal agents
- Oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B for negative regulation of insulin pathway (a promising target for treatment of diabetes and obesity)
- 11-oxa prostaglandin analogs with ocular hypotensive activity
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
이미 열람한 고객
Xin-Cheng Zhong et al.
Pharmaceutical development and technology, 26(1), 21-29 (2020-10-20)
Multidrug resistance (MDR) is a serious challenge in chemotherapy and also a major threat to breast cancer treatment. As an intracellular energy factory, mitochondria provide energy for drug efflux and are deeply involved in multidrug resistance. Mitochondrial targeted delivery of
Min Han et al.
Molecular pharmaceutics, 11(8), 2640-2649 (2014-05-09)
In this study, doxorubicin (DOX) was conjugated to a lipophilic triphenylphosphonium (TPP) that is selectively taken up by the mitochondrial membrane of cells. This new derivative of DOX, i.e., TPP-DOX, was characterized by infrared spectroscopy (IR), nuclear magnetic resonance ((1)H
Hongqiao Zhou et al.
Biomaterials science, 6(6), 1535-1545 (2018-04-20)
Although microwave (MW) thermal therapy has been widely studied for the treatment of tumors due to its less invasiveness, recurrence of tumors is still observed because of the relatively low bioavailability of MW sensitizers. For enhancing the bioavailability of MW
L Palanikumar et al.
Communications biology, 3(1), 95-95 (2020-03-05)
The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such as poor circulation stability and targeting inefficiency. Here, we have utilized a simple approach to prepare biocompatible and biodegradable pH-responsive hybrid NPs that
Niloufar Maghsoudnia et al.
Journal of drug targeting, 28(7-8), 818-830 (2020-05-27)
Many biological mechanisms including cellular metabolism and cell death are regulated by mitochondria known as powerhouse of the cell. Recently, let-7b, a tumour-suppressor microRNA has been detected in mitochondria of human cells targeting several mitochondrial-encoded respiratory chain genes. Triphenylphosphonium cation
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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