305472

Trimethyl orthoformate

anhydrous, 99.8%

• 동의어(들): TMOF, Trimethoxymethane
• Linear Formula: CH(OCH₃)₃
• CAS Number: 149-73-5
• Molecular Weight: 106.12
• Beilstein: 969215
• EC Number: 205-745-7
• MDL number: MFCD00008483
• UNSPSC 코드: 12352112
• eCl@ss: 39021015
• PubChem Substance ID: 24858434
• NACRES: NA.22

속성

• Grade: anhydrous
• Quality Level: 200
• vapor density: 3.67 (vs air)
• vapor pressure: 23.5 mmHg ( 20 °C); 40 mmHg ( 30 °C); 57 mmHg ( 40 °C)
• 분석: 99.8%
• 형태: liquid
• expl. lim.: 5.1 %
• 불순물: <0.002% water; <0.005% water (100 mL pkg)
• 증발 잔류물: <0.0005%
• refractive index: n20/D 1.379 (lit.)
• bp: 101-102 °C (lit.)
• density: 0.97 g/mL at 25 °C (lit.)
• SMILES string: COC(OC)OC
• InChI: 1S/C4H10O3/c1-5-4(6-2)7-3/h4H,1-3H3
• InChI key: PYOKUURKVVELLB-UHFFFAOYSA-N

설명

일반 설명

Trimethyl orthoformate is a commonly used reagent in organic synthesis for the preparation of useful building blocks. It is also used to introduce the protecting group for aldehydes by the preparation of acetals. Acetals can be deprotected back to the aldehyde by using acid catalysts.

애플리케이션

Trimethyl orthoformate can be used:

• To convert sulfonic acids to methyl esters.
• To convert 2-acylcyclohexanones to the corresponding acetal derivatives.
• To mediate Pinacol reaction of various 1,2-diols with tin(IV) chloride without the formation of water.
• To synthesize 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation with amine and sodium azide catalyzed by indium triflate under solvent-free conditions.
• For the N-methylation of amines in the presence of sulfuric acid.

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H319,H335
• 예방조치 성명서: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): 55.4 °F - closed cup
• Flash Point (°C): 13 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter