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F6300

Sigma-Aldrich

Flumazenil

>99% (HPLC), solid, benzodiazepine receptor antagonist

Synonym(s):

Ro 15-1788, Ro15-1788

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About This Item

Empirical Formula (Hill Notation):
C15H14FN3O3
CAS Number:
78755-81-4
Molecular Weight:
303.29
MDL number:
MFCD00242764
UNSPSC Code:
12352200
PubChem Substance ID:
24278437
NACRES:
NA.77

product name

Flumazenil, >99% (HPLC), solid

Quality Level

100

Assay

>99% (HPLC)

form

solid

color

white

originator

Roche

storage temp.

2-8°C

SMILES string

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23

InChI

1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key

OFBIFZUFASYYRE-UHFFFAOYSA-N

Gene Information

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
rat ... Gabra2(29706) , Gabrg1(140674)

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General description

Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.

Biochem/physiol Actions

Highly specific benzodiazepine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nahid Amini et al.
Analytical and bioanalytical chemistry, 405(4), 1303-1310 (2012-11-28)
A general method is presented for the identification of radiometabolites in plasma of human and monkey subjects after administration of positron emission tomography (PET) radioligands. The radiometabolites are first produced in vitro, using liver microsomes, subsequently separated using fast radio-liquid
Stina Syvänen et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(12), 1974-1983 (2012-11-13)
The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study
David B Rye et al.
Science translational medicine, 4(161), 161ra151-161ra151 (2012-11-24)
The biology underlying excessive daytime sleepiness (hypersomnolence) is incompletely understood. After excluding known causes of sleepiness in 32 hypersomnolent patients, we showed that, in the presence of 10 μM γ-aminobutyric acid (GABA), cerebrospinal fluid (CSF) from these subjects stimulated GABA(A)
Wolf-Dieter Heiss
Annals of the New York Academy of Sciences, 1268, 26-34 (2012-09-22)
An ischemic penumbra has the potential for functional recovery provided that local blood flow can be reestablished, but irreversible damage will develop without sufficient reperfusion, depending on the interaction of severity and duration of ischemia. With acute flows below the
Suengmok Cho et al.
Psychopharmacology, 231(14), 2825-2837 (2014-02-04)
In psychopharmacology, researchers have been interested in the hypnotic effects of terrestrial plant polyphenols and their synthetic derivatives. Phlorotannins, a marine plant polyphenol, could have potential as a source of novel hypnotic drugs. The effects of phlorotannins and major phlorotannin
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